Anti-Human Bcl-xL

Product No.: B450

[product_table name="All Top" skus="B450"]

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Target
Bcl-xL
Product Type
Polyclonal Antibody
Alternate Names
Basal Cell Lymphoma-Extra Large
Applications
WB

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Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
Purified Recombinant Human Bcl-xL (>98%)
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Rabbit Anti-Human Basal Cell Lymphoma-Extra Large (Bcl-xL) recognizes Human Bcl-xL. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer.1 Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis.2,3 These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene.4 Its high expression in tumors is correlated with advanced disease and poor prognosis.5 Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.6,7
PubMed

References & Citations

1. Lockshin, RA. et al. (2000) Cell Death Differ. 7:2-7.
2. Cory, S. et al. (2003) Oncogene 22:8590-607.
3. Heiser, D. et al. (2004) Exp. Geron. 39:1125-35.
4. Gonzalez-Garcia, M. et al. (1994) Development 120:3033-42.
General Western Blot Protocol

Certificate of Analysis

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Prod No.
Description
B450
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.