Anti-Human Bfl-1 (CT)

Pricing & Details

Product No.B453
Protein
Bfl-1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Bcl-2-related protein A1, Hemopoietic-specific early response protein
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
B453-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
B453-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:B484
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Bfl-1 recognizes an epitope near the C-terminus of human and mouse Bfl-1. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells and is caused by caspase activation. Proteins that comprise the Bcl-2 family appear to control the activation of these enzymes. One such member is multi-domain antiapoptotic protein Bfl-1, which is overexpressed in stomach and other cancers. Bfl-1 can interact with Bax and suppress apoptosis by inhibiting the release of cytochrome c and caspase-3 activation. It is upregulated in cisplatin-resistant human bladder tumor, suggesting that its expression may be important for cisplatin resistance and inhibition of apoptosis in cancer cells. At least two isoforms of Bfl-1 are known to exist. Presumably due to post-translational modifications, Bfl-1 is often observed at higher molecular weight in SDS-PAGE than its predicted molecular weight would suggest.

Antigen Details

Protein
PubMed

References & Citations

1. Lockshin, RA. et al. (2000) Cell Death Differ. 7:2-7.
2. Choi, SS. et al. (1995) Oncogene 11:1693-8.
3. Kim, JK. et al. (2004) Cancer Lett. 212:61-70.
4. Zhang, H. et al. (2000) J. Biol. Chem. 275:11092-9
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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