Anti-Human Bnip3L (Intermediate Domain)
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Antibody DetailsProduct DetailsReactive Species Human Host Species Rabbit Immunogen PN:B371 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2828170 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Human Bnip3L recognizes an epitope in the intermediate domain of Human Bnip3L. This polyclonal antibody was purified using affinity chromatography. Background Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3α, and Nix (for Nip3-like protein X).1-3 Bnip3L/Bnip3α/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis.2,3 Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues.1,2 Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins. Antigen DetailsPubMed References & Citations1. Matsushima, M. et al. (1998) Genes Chromosomes Cancer 21:230-5 2. Yasuda, M. et al. (1999) Cancer Res 59:533-7 3. Chen, G. et al. (1999) J Biol Chem 274(1):7-10 4. Imazu, T. et al. (1999) Oncogene. 18:4523-9 Technical Protocols |
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