Anti-Human Casp-1 (CT)

PN:C1266

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Casp-1 recognizes an epitope near the C-terminus of Human Casp-1. This polyclonal antibody was purified using affinity chromatography.

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.^1,2 Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18.^3,4 Caspase-1 was initially identified as an IL-1β-converting enzyme;⁵ later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3⁶ whose overexpression can induce apoptosis in fibroblasts.⁷

1. Martinon, F. and Tschopp, J. (2004) CCell 117:561-74.
2. Zhivotovsky, B. and Orrenius, S. (2005) Biochim. Biophys. Res. Comm. 331:859-67.
3. Kuida, K. et al. (1995) Science M 267:2000-3.
4. Gracie, JA. et al. (2003) J. Leukoc. Biol. 73:213-224.