Anti-Human Caspase-10 (CT)

Pricing & Details

Product No.C1114
Protein
Caspase-10
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
FLICE2, ALPS2
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1114-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1114-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1127
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Caspase-10 recognizes an epitope near the C-terminus of mouse, rat and human Caspase-10. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch41,2 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis1. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death. Caspase-10 is expressed in many tissues and cell lines.

Antigen Details

Protein

References & Citations

1. Vincenz, C. and Dixit, VM. (1997) J. Biol. Chem. 272:6578-6583
2. Fernandes-Alnemri, T. et al. (1996) Proc. Natl. Acad. Sci. USA. 93:7464-69
3. Cohen, GM. (1997) Biochem J 326:1-16
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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