Anti-Human Caspase-8 (Intermediate Domain)

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Pricing & Details

Product No.C1241
Protein
Caspase-8
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
FLICE, MACH, Mch5, CASP8, CAP4, MGC78473
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1241-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1241-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
Purified Recombinant Human Caspase-8 (>98%)
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Caspase-8 recognizes an epitope in the intermediate domain of mouse and human Caspase-8. This polyclonal antibody was purified using affinity chromatography.
Background
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.1,2 The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death.3 Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex.4 The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation.5 FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.6

caspase-8 presents a promising target to restore defective apoptosis programs in cancers in order to overcome resistance.

Antigen Details

Protein
PubMed

References & Citations

1. Martinon, F. and Tschopp, J. (2004) Cell 117:561-74.
2. Zhivotovsky, B. and Orrenius, S. (2005) Biochim. Biophys. Res. Comm. 331:859-67.
3. Wolf, BB. and Green, DR. (1999) J. Biol. Chem. 274:20049-52.
4. Dixit, VM. et al. (1996) Cell 85:817-27.
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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