Anti-Human Caspase-9 (Intermediate Domain-1)

Anti-Human Caspase-9 (Intermediate Domain-1)

Product No.: C1112

[product_table name="All Top" skus="C1112"]

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Target
Caspase-9
Product Type
Polyclonal Antibody
Alternate Names
Mch6, Apaf-3
Applications
WB

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:C1130
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Caspase-9 recognizes Human Caspase-9. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3.1-3 Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation3 Caspase-9 is also activated by granzyme B and CPP32.1,2 Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis.3 Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD.4 Caspase-9 is expressed in a variety of human tissues.1,2

Antigen Details

PubMed

References & Citations

1. Duan, H. et al. (1996) J Biol Chem 271:16720-4
2. Srinivasula, SM. et al.(1996) J Biol Chem 271:27099-106
3. Li, P. et al. (1997) Cell 91:479-89
4. Pan, G. et al. (1998) J Biol Chem273:5841-5
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.