Anti-Human Caspase-9 (Intermediate Domain-2)

PN:C1131

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human Caspase-9 recognizes an epitope in the intermediate domain of Human Caspase-9. This polyclonal antibody was purified using affinity chromatography.

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3.^1-3 Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation³ Caspase-9 is also activated by granzyme B and CPP32.^1,2 Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis.³ Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD.⁴ Caspase-9 is expressed in a variety of human tissues.^1,2

1. Duan, H. et al. (1996) J Biol Chem 271:16720-4