Anti-Human CCR2 - APC - Leinco Technologies

Anti-Human CCR2 – APC

Product No.: C1540


Clone 48607 Target CCR2 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names CD192 Isotype IgG2b Applications FC


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Antibody Details Product Details Reactive Species Human Host Species Mouse Formulation This monoclonal antibody is conjugated to allophycocyanin (APC) and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 0.1% sodium azide as a preservative. Storage and Handling This Allophycocyanin (APC) conjugate is stable for at least twelve months when stored at 2-8°C protected from light. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Red Laser (633 nm) RRIDAB_2828610 Applications and Recommended Usage? Quality Tested by Leinco Flow Cytometry: This conjugate has been pre-diluted to use approximately 10 µl per test when staining cells for flow cytometry. A typical test sample constitutes approximately 50 µl of packed whole blood or 1 x 10⁶ continuous passage or activated cell cultures that have been centrifuged at 500 X g for five minutes and resuspended in 200-400 µl of 1X PBS. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Mouse Anti-Human CCR2 (Clone 48607) recognizes an epitope on Human CCR2. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background CCR2, short for chemokine (C-C motif) receptor 2, is a chemokine receptor. CCR2 has also recently been designated CD192 (cluster of differentiation 192). This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. PubMed CCR2 NCBI Gene Bank ID 729230 UniProt.org Information on Uniprot.org References & Citations View product citations for antibody PRODUCT_CODE on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Mouse

Formulation

This monoclonal antibody is conjugated to allophycocyanin (APC) and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 0.1% sodium azide as a preservative.

Storage and Handling

This Allophycocyanin (APC) conjugate is stable for at least twelve months when stored at 2-8°C protected from light. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

Excitation Laser

Red Laser (633 nm)

RRIDAB_2828610

Applications and Recommended Usage?
Quality Tested by Leinco

Flow Cytometry: This conjugate has been pre-diluted to use approximately 10 µl per test when staining cells for flow cytometry. A typical test sample constitutes approximately 50 µl of packed whole blood or 1 x 10⁶ continuous passage or activated cell cultures that have been centrifuged at 500 X g for five minutes and resuspended in 200-400 µl of 1X PBS.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Mouse Anti-Human CCR2 (Clone 48607) recognizes an epitope on Human CCR2. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background

CCR2, short for chemokine (C-C motif) receptor 2, is a chemokine receptor. CCR2 has also recently been designated CD192 (cluster of differentiation 192). This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.

PubMed

CCR2

NCBI Gene Bank ID

729230

UniProt.org

Information on Uniprot.org