Anti-Human CCR3 (CT)

Anti-Human CCR3 (CT)

Product No.: C1304

[product_table name="All Top" skus="C1304"]

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Target
CCR3
Product Type
Polyclonal Antibody
Alternate Names
CC Chemokine Receptor-3, Eosinophil Eotaxin Receptor
Applications
ICC
,
IHC FFPE
,
WB

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
Purified Recombinant Human CCR3 (NP_847899)
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Description

Specificity
Rabbit Anti-Human CCR3 recognizes an epitope near the C-terminus of Human, Mouse and Rat CCR3. This polyclonal antibody was purified using affinity chromatography.
Background
Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS.3,4 High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.
PubMed

References & Citations

1. Feng, Y. et al. (1996) Science 272:872 2. Deng, H. et al. (1996) Nature 381:661 3. Choe, H. et al. (1996) Cell 85:1135 4. He, J. et al. (1997) Nature 385:645
ICC
IHC FFPE
General Western Blot Protocol

Certificate of Analysis

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Prod No.
Description
C1305
C1304
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.