Anti-Human CD257 (BAFF) (Tabalumab) – Dylight® 488
Pricing & Details
Antibody DetailsProduct DetailsReactivity Species Human/Cynomolgus Monkey/Rabbit Expression Host HEK-293 FC Effector Activity Active Immunogen Original antibody was raised against soluble human BAFF. Product Concentration 0.2 mg/ml Formulation This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only (RUO). Non-Therapeutic. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Blue Laser (493 nm) RRIDAB_2893909 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for Tabalumab biosimilar antibody for staining cells in flow cytometry is ≤ 0.25 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Other Applications Reported In Literature ? FA Additional Reported Applications For Relevant Conjugates ? N IP WB ELISA Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Tabalumab. Tabalumab neutralizes soluble human, cynomolgus monkey, and rabbit BAFF. Additionally, Tabalumab neutralizes membrane-bound BAFF. This product is for research use only. Antigen Distribution BAFF is expressed on various cell types including monocytes, dendritic cells and bone marrow stromal cells. Background Tabalumab is a human monoclonal anti-B-cell activating factor (BAFF) antibody intended for the treatment of autoimmune diseases and B cell malignancies.1 BAFF is a membrane-bound, type II transmembrane protein that belongs to the tumor necrosis factor (TNF) ligand family and is the ligand for BR3, TACI, and BCMA. BAFF is an immunostimulant necessary for maintaining normal immunity. This cytokine has also been shown to play an important role in the proliferation and differentiation of B cells. An inadequate level of BAFF leads to immunodeficiency whilst an elevated level of BAFF causes unusually high antibody production that results in the development of autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Additionally, BAFF has been found in renal transplant biopsies with acute rejection.2 Furthermore, BAFF may be a mediator of food-related inflammation, and is associated with multiple dietary ailments including celiac disease, insulin resistance, diabetes, and obesity.3 Interestingly, it is suspected that BAFF may be involved in non-IgE-mediated reactions because there is no known correlation between BAFF and IgE.4 More research is needed to unlock the enormous therapeutic potential for BAFF antagonists. This cost-effective, research-grade Anti-Human CD257 (BAFF) (Tabalumab) utilizes the same variable regions from the therapeutic antibody Tabalumab making it ideal for research projects. Antigen DetailsProtein Ligand/Receptor BR3, TACI, BCMA PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Biology . Costimulatory Molecules . Immunology . Signal Transduction . Stem Cell References & Citations1. Manetta, J. et al. (2014) J Inflamm Res. 7: 121–131 2. Clatworthy, MR. et al. (2013) Transplantation. 96(4): 413–420. 3. Lied, GA. and Berstad, A. (2011) Scand J Immunol. 73(1):1-7. 4. Büchler, JR. and Cano, MN. (1986) Jpn Heart J. 27(1):117-22. Technical Protocols |
Formats Available
Prod No. | Description |
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LT1400 |
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LT1405 |
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LT1404 |
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LT1401 |
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LT1411 |
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LT1406 |
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LT1407 |
