Anti-Human cIAP (CT)

PN:C1288

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

Rabbit Anti-Human cIAP recognizes an epitope near the C-terminus of mouse and human c-IAP. The antibody detects both c-IAP1 and c-IAP2. This polyclonal antibody was purified using affinity chromatography.

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases.¹ The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7.^2,3 The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α by its receptor.^2,4 Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP.⁵ Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.⁶

1. Schimmer, AD. (2004) Cancer Res. 64:7183-90.
2. Goeddel, D. et al. (1995) Cell 83:1243-52.
3. Reed, JC. et al. (1998) EMBO J. 17:2215-23. < br> 4. Ashwell, JD. et al. (2002) Nature 416:345-7.