Anti-Human cIAP (CT)

Pricing & Details

Product No.C1250
Protein
cIAP
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Inhibitor of Apoptosis Protein, HIAP
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1250-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
C1250-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:C1288
Product Concentration
1.0 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human cIAP recognizes an epitope near the C-terminus of mouse and human c-IAP. The antibody detects both c-IAP1 and c-IAP2. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases.1 The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7.2,3 The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α by its receptor.2,4 Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP.5 Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.6

Antigen Details

Protein
PubMed

References & Citations

1. Schimmer, AD. (2004) Cancer Res. 64:7183-90.
2. Goeddel, D. et al. (1995) Cell 83:1243-52.
3. Reed, JC. et al. (1998) EMBO J. 17:2215-23. < br> 4. Ashwell, JD. et al. (2002) Nature 416:345-7.
IHC
General Western Blot Protocol
Prod No.
Description
C1288
C1250
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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