Anti-Human DR3 (NT)

Anti-Human DR3 (NT)

Product No.: D253

[product_table name="All Top" skus="D253"]

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Target
DR3
Product Type
Polyclonal Antibody
Alternate Names
Wsl-1, Apo-3, TRAMP, LARD
Applications
WB

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Product Size

Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:D276
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DR3 recognizes an epitope near the N-terminus of mouse and human DR3. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-κB activation.

Antigen Details

PubMed

References & Citations

1. Chinnaiyan, AM. et al. (1996) Science 274:990-2.
2. Kitson, J. et al. (1996) Nature 384:372-5.
3. Marsters, SA. et al. (1996) Curr Biol 6:1669-76.
4. Bodmer, JL. et al. (1997) Immunity6:79-88.
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.