Anti-Human DR3 (CT)

Pricing & Details

Product No.D252
Protein
DR3
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Wsl-1, Apo-3, TRAMP, LARD
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
D252-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
D252-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:D274
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human DR3 recognizes an epitope near the C-terminus of mouse, rat and human DR3. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-κB activation.

Antigen Details

Protein
PubMed

References & Citations

1. Chinnaiyan, AM. et al. (1996) Science 274:990-2.
2. Kitson, J. et al. (1996) Nature 384:372-5.
3. Marsters, SA. et al. (1996) Curr Biol 6:1669-76.
4. Bodmer, JL. et al. (1997) Immunity6:79-88.
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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