This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human F1A-α recognizes an epitope near the C-terminus of mouse, rat and human F1A-α. This polyclonal antibody was purified using affinity chromatography.
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aα and FEM1b.1,2 F1Aα/FEM1β is the homologue of C. elegans sex determining protein FEM-1.1,2 FEM-1/F1Aα is cleaved by CED-3 and caspase.3 FEM-1/F1Aα associates with CED-4 and its mammalian homologue Apaf-1.3 Overexpression of F1Aα induces apoptosis. F1Aα is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aα is expressed in a variety of human and mouse tissues.1,2
References & Citations
1. Chan, SL. et al. (1999) J Biol Chem. 274(45):32461-8.
2. Ventura-Holman, T. and Maher, JF. (2000) Biochem Biophys Res Commun 267(1):317-20
3. Chan, SL. et al. (2000) J Biol Chem. 275 (24):17925-8.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.