Anti-Human F1A-α (CT)

PN:F144

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human F1A-α recognizes an epitope near the C-terminus of mouse, rat and human F1A-α. This polyclonal antibody was purified using affinity chromatography.

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aα and FEM1b.^1,2 F1Aα/FEM1β is the homologue of C. elegans sex determining protein FEM-1.^1,2 FEM-1/F1Aα is cleaved by CED-3 and caspase.³ FEM-1/F1Aα associates with CED-4 and its mammalian homologue Apaf-1.³ Overexpression of F1Aα induces apoptosis. F1Aα is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aα is expressed in a variety of human and mouse tissues.^1,2

1. Chan, SL. et al. (1999) J Biol Chem. 274(45):32461-8.
2. Ventura-Holman, T. and Maher, JF. (2000) Biochem Biophys Res Commun 267(1):317-20
3. Chan, SL. et al. (2000) J Biol Chem. 275 (24):17925-8.