Anti-Human FLIP-α (CT)

Anti-Human FLIP-α (CT)

Product No.: F140

[product_table name="All Top" skus="F140"]

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Target
FLICE Inhibitor Protein-α
Product Type
Polyclonal Antibody
Alternate Names
Casper, I-FLICE, FLAME-1, CASH, CLARP
Applications
IHC FFPE
,
WB

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Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:F146
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human FLICE Inhibitor Protein-α (FLIP-α) recognizes an epitope near the C-terminus of Human, Mouse and Rat FLIP-α. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively.1,2 The human FLIP was also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPα, β, γ, and δ, respectively.

Antigen Details

References & Citations

1. Thome, M. et al. (1997) Nature 386:517
2. Irmler, M. et al. (1997) Nature 388:190
3. Shu, HB. et al. (1997) Immunity 6:751
4. Hu, S. et al. (1997) J. Biol. Chem. 272:17255
IHC FFPE
General Western Blot Protocol
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Prod No.
Description
F140
Products are for research use only. Not for use in diagnostic or therapeutic procedures.