Anti-Human GITRL

Pricing & Details

Product No.G620
Protein
GITRL
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
AITRL
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
G620-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
G620-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Product Concentration
0.2 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human GITRL recognizes Human and Mouse GITRL. This polyclonal antibody was purified using affinity chromatography.
Background
The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases (reviewed in 1). The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions.2,3 Its ligand GITRL is expressed in endothelial and antigen-presenting cells4 and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR.5 Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.4

Antigen Details

Protein
PubMed

References & Citations

1. Gaur, U. et al. (2003) Biochem. Pharmacol. 66:1403
2. Ronchetti, S. et al (2002) Blood 100:350
3. Shimizu, J. et al. (2002) Nat. Immunol. 3:135
4. Gurney, AL. et al. (1999) Curr. Biol. 9:215
IHC
General Western Blot Protocol
Prod No.
Description
G620
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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