Pricing & Details

Product No.H1458
Protein
Hrk
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Harakiri, Neuronal Death Protein DP5
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
H1458-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
H1458-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:H1460
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Hrk recognizes mouse, rat and human Hrk. This polyclonal antibody was purified using affinity chromatography.
Background
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL. Despite its predicted molecular weight, Hrk often migrates at 12-15 kDa.

Antigen Details

Protein
PubMed

References & Citations

1. Lockshin, RA. et al. (2000) Cell Death Differ. 7 (1):2-7.
2. Imaizumi, K. et al. (1997) J Biol Chem. 272(30):18842-8.
3. Núñez, G. et al. (1997) EMBO J 16:1686-1694.
General Western Blot Protocol
Prod No.
Description
H1460
H1458
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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