Anti-Human ILPIP (Intermediate Domain)

PN:I-496

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human ILPIP recognizes mouse, rat and human ILPIP. This polyclonal antibody was purified using affinity chromatography.

ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family.¹ Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 converting enzyme of Fas-induced apotosis.^1,2 This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival,³ suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.

1. Sanna, MG. et al. (2002) J Biol Chem. 277(34):30454-62.
2. Sanna, MG. et al. (1998) Proc Natl Acad Sci U S A. 95(11):6015-20.
3. Nishigaki, K. et al. (2003) J Biol Chem. 278(15):13520-30.