Anti-Human ILPIP (Intermediate Domain)

Anti-Human ILPIP (Intermediate Domain)

Product No.: I-489

[product_table name="All Top" skus="I-489"]

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Target
ILPIP
Product Type
Polyclonal Antibody
Alternate Names
ILP-Interacting Protein
Applications
IHC FFPE
,
WB

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Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:I-496
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human ILPIP recognizes mouse, rat and human ILPIP. This polyclonal antibody was purified using affinity chromatography.
Background
ILPIP (ILP-interacting protein) has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family.1 Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 converting enzyme of Fas-induced apotosis.1,2 This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival,3 suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.

Antigen Details

PubMed

References & Citations

1. Sanna, MG. et al. (2002) J Biol Chem. 277(34):30454-62.
2. Sanna, MG. et al. (1998) Proc Natl Acad Sci U S A. 95(11):6015-20.
3. Nishigaki, K. et al. (2003) J Biol Chem. 278(15):13520-30.
IHC FFPE
General Western Blot Protocol

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.