Anti-Human Luteinizing Hormone (LH) Beta (Clone 196O) – HRP

Anti-Human Luteinizing Hormone (LH) Beta (Clone 196O) – HRP

Product No.: H119

[product_table name="All Top" skus="H119"]

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Clone
196
Target
Luteinizing Hormone Beta
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
IgG
Applications
ELISA Det

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Mouse
Immunogen
Purified Recombinant Human LH=β (>98%)
Product Concentration
0.5 mg/ml
Formulation
This horseradish peroxidase conjugate is supplied in a specially formulated stabilization diluent.(Leinco Prod. No.: S509)
Storage and Handling
Stable for at least one year when stored at 2°C - 8°C. Do not freeze.
Cross Reactivity
Paired with Leinco Prod. No. F103 Clone No. 176: LH 100%, BhCG < 1%, ihCG 57%, FSH < 1%, TSH 40%, ihCG > 40%, FSH < 1%, TSH < 1%
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Mouse Anti-Human Luteinizing Hormone Beta (LH=β) (Clone 196) recognizes Human Luteinizing Hormone Beta. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Luteinizing hormone (LH) is a hormone synthesized and secreted by gonadotropes in the anterior lobe of the pituitary gland. In concert with the other pituitary gonadotropin follicle stimulating hormone (FSH) it is necessary for proper reproductive function. In the female, an acute rise of LH – the LH surge – triggers ovulation. In the male, where LH had also been called Interstitial Cell Stimulating Hormone (ICSH), it stimulates Leydig cell production of testosterone. LH is a glycoprotein. Each monomeric unit is a protein molecule with a sugar attached to it; two of these make the full, functional protein. Its structure is similar to the other glycoproteins, FSH, TSH, and hCG. The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two disulfide bridges. The alpha subunits of LH, FSH, TSH, and hCG are identical, and contain 92 amino acids. The beta subunits vary. LH has a beta subunit of 121 amino acids (LHB) that confers its specific biologic action and is responsible for interaction with the LH receptor. This beta subunit contains the same amino acids in sequence as the beta sub unit of hCG and both stimulate the same receptor, however, the hCG beta subunit contains an additional 24 amino acids, and both hormones differ in the composition of their sugar moieties. The different composition of these oligosaccharides affects bioactivity and speed of degradation. The biologic half-life of LH is 20 minutes, shorter than that of FSH (3-4 hours) or hCG (24 hours).

Antigen Details

Research Area
Hormones
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IVD Raw Material
ELISA Det

Certificate of Analysis

Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.