Anti-Human Lysosome Associated Membrane Protein-2 (LAMP-2)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Lysosome Associated Membrane Protein-2 (LAMP-2)

Pricing & Details

Product No.L169
Protein
LAMP-2
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FF
,
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
L169-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
L169-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:L171
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Lysosome Associated Membrane Protein 2 (LAMP-2) recognizes mouse and human LAMP-2. This polyclonal antibody was purified using affinity chromatography.
Background
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components1,2 and is negatively regulated by TOR (Target of rapamycin).3 LAMP-2, a highly glycosylated protein associated with the lysosome,4 has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon’s disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.

Antigen Details

Protein
PubMed

References & Citations

1. Gozuacik, D and Kimchi, A. (2004) Oncogene. 23:2891-906.
2. Kisen, GO. et al. (1993) Carcinogenesis 14:2501-5.
3. Shintanim, T. et al. (2000) J. Cell. Biol. 150:1507-13.
4. Gabel, CA. et al. (1990) J. Biol. Chem. 265:12036-43.
5. Suter, A. et al. (2000) Nature 406(6798):902-6.
6. Hirano, M. et al. (2000) Nature. 406(6798):906-10.
7. Fambrough, DM. et al. (1995) DNA Cell Biol. 14:863-7.
IHC
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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