Data
Antibody DetailsProduct DetailsReactivity Species Human Host Species Rabbit Immunogen PN:M1216 Product Concentration 0.5 mg/ml Formulation This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative. Storage and Handling This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient RRIDAB_2831241 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Anti-Human Mcl-1 recognizes an epitope in the intermediate domain of Human Mcl-1. This polyclonal antibody was purified using affinity chromatography. Background Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival (reviewed in 1). While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak.2,3 Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals.3 Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death. Antigen DetailsProtein PubMed References & Citations1. Edwards, SW. et al. (2004) Biochem Soc Trans. 32:489 2. Cuconati, A. et al. (2003) Genes and Dev. 17:2922 3. Opferman, JT. et al. (2003) Nature 426:671 4. Kozopas, KM. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3516 Technical Protocols |
Related Products
Prod No. | Description |
---|---|
M1215 |
|
M1216 |
|
M1217 |
|
M1211 |
|
M1213 |
|
M1212 |
