Anti-Human Mcl-1 (Intermediate Domain)

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Pricing & Details

Product No.M1212
Protein
Mcl-1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Myeloid Cell Leukemia-1
Applications
ELISA Indirect
,
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
M1212-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
M1212-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:M1216
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Mcl-1 recognizes an epitope in the intermediate domain of Human Mcl-1. This polyclonal antibody was purified using affinity chromatography.
Background
Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival (reviewed in 1). While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak.2,3 Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals.3 Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Antigen Details

Protein
PubMed

References & Citations

1. Edwards, SW. et al. (2004) Biochem Soc Trans. 32:489
2. Cuconati, A. et al. (2003) Genes and Dev. 17:2922
3. Opferman, JT. et al. (2003) Nature 426:671
4. Kozopas, KM. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3516
Indirect Elisa Protocol
IHC
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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