Anti-Human NAIP (CT)

Pricing & Details

Product No.N156
Protein
NAIP
Formats AvailableView All
Product Type
Polyclonal Antibody
Applications
IHC FFPE
,
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
N156-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
N156-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:N169
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human NAIP recognizes an epitope near the C-terminus of Human NAIP. This polyclonal antibody was purified using affinity chromatography.
Background
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy.1,2 Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO.4 suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.

Antigen Details

Protein
PubMed

References & Citations

1. Roy, N. et al. (1995) Cell 80:167
2. Liston, P. et al. (2003) Oncogene 22:8568
3. Verhagen, AM. et al. (2001) Genome Biol. 2(7):REVIEWS3009
4. Davoodi, J. et al. (2004) J. Biol. Chem. 279:40622
IHC
General Western Blot Protocol
Prod No.
Description
N169
N156
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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