This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human NOD2 recognizes an epitope near the C-terminus of Human NOD2. This polyclonal antibody was purified using affinity chromatography.
Apaf-1 and NOD1 are members of a new family,1 which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2.2 NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn’s disease3,4 that is a main type of chronic inflammatory bowel disease.
References & Citations
1. Inohara, N. et al. (1999) J. Biol. Chem. 274:14560
2. Ogura, Y. et al. (2001) J. Biol. Chem. 276:4812
3. Hugot, JP. et al. (2001) Nature 411:599
4. Ogura, Y. et al. (2001) Nature 411:603
Products are for research use only. Not for use in diagnostic or therapeutic procedures.