Anti-Human NOD2 (CT)

PN:N172

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Human NOD2 recognizes an epitope near the C-terminus of Human NOD2. This polyclonal antibody was purified using affinity chromatography.

Apaf-1 and NOD1 are members of a new family,¹ which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2.² NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn’s disease^3,4 that is a main type of chronic inflammatory bowel disease.

1. Inohara, N. et al. (1999) J. Biol. Chem. 274:14560
2. Ogura, Y. et al. (2001) J. Biol. Chem. 276:4812
3. Hugot, JP. et al. (2001) Nature 411:599
4. Ogura, Y. et al. (2001) Nature 411:603