Anti-Human PAX-8 Antibody (34066)

Recombinant human PAX-8.

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

Liquid

Purified by immunoaffinity chromatography

Store at 2-8°C. Do not freeze.

Next Day 2-8°C

Mouse Monoclonal Antibody specific to PAX-8

PAX-8 is a member of the paired box (PAX) family of transcription factors which are key regulators in early development. This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. The PAX-8 protein is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes but is absent from normal ovarian surface epithelial cells. PAX-8 is also not expressed in normal lung or lung carcinomas. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors.

Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.