Anti-Human SOX-10 Antibody (34071)
Anti-Human SOX-10 Antibody (34071)
Product No.: 34071
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| Clone G010.1 Target SOX-10 Formats AvailableView All Product Type Monoclonal Isotype Mouse IgG2b Applications IHC |
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| Select Product Size | Qty Max: Min: 1 Step: 1 $175.00 |
Data
Immunohistochemistry: Detection of SOX-10 in human melanoma with #34071 diluted 1:100-1:200. - -
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Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Recombinant human SOX-10. Formulation Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide. State of Matter Liquid Product Preparation Purified by immunoaffinity chromatography Storage and Handling Store at 2-8°C. Do not freeze. Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Mouse Monoclonal Antibody specific to SOX-10 Background SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurobromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg- Shah and Waardenburg-Hirschsprung disease. Function Transcription factor that plays a central role in developing and mature glia (By similarity). Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity). Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity). Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). Transcriptional activator of MBP, via binding to the gene promoter (By similarity). {UniProtKB:O55170, UniProtKB:Q04888, PubMed:21965087}. NCBI Gene Bank ID UniProt.org Research Area Cancer Research References & Citations |
Formats Available
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Prod No. | Description |
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| 34071 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
