Anti-Human Suppressor of Cytokine Signaling 1 (NT) (SOCS1)

Home/Primary Monoclonal Antibodies/Apoptosis & Cell Biology/Anti-Human Suppressor of Cytokine Signaling 1 (NT) (SOCS1)

Pricing & Details

Product No.S524
Protein
SOCS1
Formats AvailableView All
Product Type
Polyclonal Antibody
Alternate Names
Suppressor of Cytokine Signaling 1, JAK-Binding Protein, JAB
Applications
WB
Prod No.
Size
Price
Avail.
Qty
Add to cart
S524-20ug
20 µg
$195.00
In stock
Max:
Min: 1
Step: 1
S524-0.1 mg
0.1 mg
$397.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Data

Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
PN:S534
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human Suppressor of Cytokine Signaling 1 (SOCS1) recognizes an epitope near the N-terminus of Human SOCS1. This polyclonal antibody was purified using affinity chromatography.
Background
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines.1 SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase.2 SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome.3 It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.4

Antigen Details

Protein
PubMed

References & Citations

1. Rakesh, K. et al. (2005) Biochem. Pharm. 70:649
2. O’Shea, JJ. et al. (2002) Cell 109:S121
3. Kile, BT. et al. (2002) Trends Biochem. Sci. 27:235
4. Mansell, A. et al. (2006) Nat. Immunol. 7:148
General Western Blot Protocol
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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