Anti-Human TANK (CT)

Anti-Human TANK (CT)

Product No.: T277

[product_table name="All Top" skus="T277"]

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Target
TANK
Product Type
Polyclonal Antibody
Alternate Names
TRAF Family Member-Associated NF-kappaB Activator, I-TRAF
Applications
IHC FFPE
,
WB

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Product Size

Data

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Antibody Details

Product Details

Reactive Species
Human
Host Species
Rabbit
Immunogen
PN:T299
Product Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
USA
Shipping
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Anti-Human TANK recognizes an epitope near the C-terminus of Human, Mouse and Rat TANK. This polyclonal antibody was purified using affinity chromatography.
Background
TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-κB. This activation of NF-κB occurs through an association with the kinases IKKε and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IκB complex. This suggests that in addition to the possibility that TBK1 and IKKε activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-κB proteins. At least two isoforms of TANK are known to exist.

Antigen Details

PubMed

References & Citations

1. Cheng, G. et al. (1996) Genes Dev. 10:963
2. Rothe, M. et al. (1996) Proc. Natl. Acad. Sci. USA 93:8241
3. Pomerantz, JL. et al. (1999) EMBO J. 18:6694
4. Chariot, A. et al. (2002) J. Biol. Chem. 277:37029
IHC FFPE
General Western Blot Protocol
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.