Anti-Human TGF-β Activated Protein Kinase 1 (TAK1)

PN:T303

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

Rabbit Anti-Human TGF-β Activated Protein Kinase 1 (TAK1) recognizes Human, Mouse and Rat TAK1. This polyclonal antibody was purified using affinity chromatography.

TAK1 (TGF-β; activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7).¹ It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-Β and members of the Toll-IL-1R (TIR) superfamily,² thus acting as an intermediate in both proliferative and innate and adaptive immune responses.³ TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3.⁴ Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation, while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity.

1. Yamaguchi, K. et al. (1995) Science 270:2008
2. Irie, T. et al. (2000) FEBS Lett. 467:160
3. Akira, S. et al. (2004) Nat. Rev. Immunol. 4:499
4. Jiang, Z. et al. (2002) Mol. Cell Biol. 22:7158