This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
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Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human TIM-1 recognizes an epitope in the intermediate domain of Human, Mouse and Rat TIM-1. This polyclonal antibody was purified using affinity chromatography.
The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
References & Citations
1. Feigelstock, D. et al. (1998) J. Virol. 72:6621 2. Ichimura, T. et al. (1998) J. Biol. Chem. 273:4135 3. Meyers, J. H. et al. (2005) Trends Mol. Med. 11:362 4. Meyers, J. H. et al. (2005) Nat. Immunol. 6:455
Products are for research use only. Not for use in diagnostic or therapeutic procedures.