This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Handling
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Rabbit Anti-Human TIM-1 recognizes an epitope near the N-terminus of Human and Mouse TIM-1. This polyclonal antibody was purified using affinity chromatography.
The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.
References & Citations
1. Feigelstock, D. et al. (1998) J. Virol. 72:6621 2. Ichimura, T. et al. (1998) J. Biol. Chem. 273:4135 3. Meyers, J. H. et al. (2005) Trends Mol. Med. 11:362 4. Meyers, J. H. et al. (2005) Nat. Immunol. 6:455
Products are for research use only. Not for use in diagnostic or therapeutic procedures.