Anti-KLK11/Hippostatin Antibody (34008)

Product No.: 34008


Target KLK11/Hippostatin Product Type Polyclonal Alternate Names hK11, EC 3.4.21.-, Hippostasin, Serine protease 20, Trypsin-like protease [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2] Applications ELISA , WB


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Antibody Details Product Details Reactive Species Human Host Species Rabbit Immunogen Synthetic peptide corresponding to aa residues 68-82 (YIVHLGQHNLQKEEG) of human Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting : use at 1:500 dilution. Positive control: LNCaP cell lysate Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Rabbit Polyclonal Antibody specific to Hippostatin/KLK11 Background Hippostatin, also known as KLK11, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain- type and prostate-type. Hippostatin plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of KLK11 were found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma. Function Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. {PubMed:10872828, PubMed:16467084}. NCBI Gene Bank ID KLK11 UniProt.org Q9UBX7 Research Area Cancer Research References & Citations Diamandis,E.P. et al. (2002) Cancer Res. 62: 295-300. Nakamura,T et al. (2003) Prostate 54: 299-305. View product citations for antibody 34008 on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Rabbit

Immunogen

Synthetic peptide corresponding to aa residues 68-82 (YIVHLGQHNLQKEEG) of human

Product Concentration

Lot Specific

Formulation

PBS, pH 7.4.

State of Matter

Liquid

Product Preparation

Purified by peptide immuno-affinity chromatography

Storage and Handling

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Country of Origin

USA

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunoblotting : use at 1:500 dilution.

Positive control: LNCaP cell lysate

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rabbit Polyclonal Antibody specific to Hippostatin/KLK11

Background

Hippostatin, also known as KLK11, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain- type and prostate-type. Hippostatin plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of KLK11 were found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.

Function

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. {PubMed:10872828, PubMed:16467084}.

NCBI Gene Bank ID

KLK11

UniProt.org

Q9UBX7

Research Area

Cancer Research