Anti-KOS1 Antibody (28108)

Synthetic peptide corresponding to amino acids 421-434 (QNQVQSLPAGSAEP) of mouse Kos1 conjugated to KLH at the N-terminus.

PBS, pH 7.4.

Liquid

Purified by peptide immuno-affinity chromatography

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to Kos1

Kinase of embryonic stem cells (Kos1) is a non-receptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction (By similarity). Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. {PubMed:12789265, PubMed:18974114}.

Hoare, K et al. (2003) Oncogene 22: 3562-3577.