Anti-MAP-1 Antibody (11009)
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Antibody DetailsProduct DetailsReactivity Species Human Host Species Rabbit Immunogen Synthetic peptide corresponding to aa 337-351 of human MAP-1. Product Concentration Lot Specific Formulation PBS, pH 7.4 with 0.02% sodium azide
State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use at 1:500-1:1,000 dilution. A band of approx. 39kDa is detected.
Positive control: Heart or brain tissue lysate. These are recommended concentrations. Enduser should determine optimal concentrations for their applications. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Polyclonal Antibody specific to MAP-1 Background MAP-1
(Modulator of Apoptosis Protein) is a novel
Bax-associating protein. MAP-1 mediates
caspase-dependent apoptosis in
mammalian cells when overexpressed.
MAP-1 homodimerizes and associates with
the proapoptotic Bax and the prosurvival
Bcl-2 and Bcl-xL of the Bcl-2 family. Antigen DetailsFunction Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed:11060313, PubMed:16199525). Required for death receptor-dependent apoptosis (PubMed:11060313). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed:15949439). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed:33393215). {UniProtKB:Q9ERH6, PubMed:11060313, PubMed:15949439, PubMed:16199525, PubMed:33393215, PubMed:33783314}. NCBI Gene Bank ID UniProt.org Research Area Apoptosis References & CitationsTechnical Protocols |
