Anti-MAP-1 Antibody (11009)

Anti-MAP-1 Antibody (11009)

Product No.: 11009

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Target
MAP-1
Product Type
Polyclonal
Alternate Names
MAP-1, MAP1, Paraneoplastic antigen Ma4
Isotype
Rabbit
Applications
ELISA

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Select Product Size

Data

Effect of gamma irradiation and IFN-beta on IP6K2 protein levels.
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Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
Synthetic peptide corresponding to aa 337-351 of human MAP-1.
Product Concentration
Lot Specific
Formulation
PBS, pH 7.4 with 0.02% sodium azide
State of Matter
Liquid
Product Preparation
Purified by peptide immuno-affinity chromatography
Storage and Handling
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
Immunoblotting: use at 1:500-1:1,000 dilution. A band of approx. 39kDa is detected.

Positive control: Heart or brain tissue lysate.

These are recommended concentrations.

Enduser should determine optimal concentrations for their applications.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Polyclonal Antibody specific to MAP-1
Background
MAP-1 (Modulator of Apoptosis Protein) is a novel Bax-associating protein. MAP-1 mediates caspase-dependent apoptosis in mammalian cells when overexpressed. MAP-1 homodimerizes and associates with the proapoptotic Bax and the prosurvival Bcl-2 and Bcl-xL of the Bcl-2 family.

Antigen Details

Function
Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis (PubMed:11060313, PubMed:16199525). Required for death receptor-dependent apoptosis (PubMed:11060313). When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (PubMed:15949439). Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins (PubMed:33783314). Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex (PubMed:33393215). {UniProtKB:Q9ERH6, PubMed:11060313, PubMed:15949439, PubMed:16199525, PubMed:33393215, PubMed:33783314}.
NCBI Gene Bank ID
UniProt.org
Research Area
Apoptosis

References & Citations

Indirect Elisa Protocol
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.