Anti-MCT-1 Antibody (56228)

Anti-MCT-1 Antibody (56228)

Product No.: 56228

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Target
MCT-1
Product Type
Polyclonal
Alternate Names
MCT 1, Solute carrier family 16 member 1
Isotype
Rabbit
Applications
WB

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Antibody Details

Product Details

Reactivity Species
Human
Host Species
Rabbit
Immunogen
Peptide corresponding to aa 3-14 of human MCT-1 protein.
Product Concentration
Lot Specific
Formulation
PBS, pH 7.4 with 0.02% sodium azide
State of Matter
Liquid
Product Preparation
Purified by peptide immuno-affinity chromatography
Storage and Handling
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Country of Origin
USA
Shipping
Next Day 2-8°C
Applications and Recommended Usage?
Quality Tested by Leinco
Immunoblotting: use at 1:500-1:1,000 dilution. A band at approx. 20 kD is detected.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rabbit Polyclonal Antibody specific to MCT-1
Background
MCT1 is a novel gene that was identified in T-cell leukemia/lymphoma cell lines having limited homology to a region of Cyclin H. MCT-1 expression results in a shortened G1 phase and increased rate of proliferation.

Antigen Details

Function
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. {PubMed:17701893}.
NCBI Gene Bank ID
UniProt.org
Research Area
Cancer Research

References & Citations

General Western Blot Protocol
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.