Anti-MCT-1 Antibody (56228)
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Antibody DetailsProduct DetailsReactivity Species Human Host Species Rabbit Immunogen Peptide corresponding to aa 3-14 of human MCT-1 protein. Product Concentration Lot Specific Formulation PBS, pH 7.4 with 0.02% sodium azide State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use at 1:500-1:1,000 dilution. A band at approx. 20 kD is detected. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Polyclonal Antibody specific to MCT-1 Background MCT1 is a novel gene that was identified in T-cell leukemia/lymphoma cell lines
having limited homology to a region of
Cyclin H. MCT-1 expression results in a
shortened G1 phase and increased rate
of proliferation. Antigen DetailsFunction Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. {PubMed:17701893}. NCBI Gene Bank ID UniProt.org Research Area Cancer Research References & CitationsTechnical Protocols |
