Anti-Mouse Vγ 3 (TCR) – DyLight® 680

Anti-Mouse Vγ 3 (TCR) – DyLight® 680

Product No.: T571

[product_table name="All Top" skus="T571"]

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Clone
536
Target
Vγ 3 T-Cell Receptor
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
IgG
Applications
FC

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Product Size
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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Syrian Hamster
Immunogen
Purified Recombinant Mouse TCR (>98%)
Product Concentration
0.5 mg/ml
Formulation
This DyLight<sup>®</sup> 680 conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This DyLight® 680 conjugate is stable when stored at 2-8° C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Syrian Hamster Anti-Mouse Vγ 3 T-Cell Receptor (TCR) (Clone 536) recognizes an epitope on Mouse TCR. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution
The antibody 536 stained less than 1% of cells in adult thymus (AKR), splenocytes, lymph node, adult CD4-8- thymocytes, and adult CD4-8-, T splenocyte. 92% of day 14 old BALB/C fetal thymus, 86% of C57BL/6 dEC (Thy-1+) and 94% of AKR dEC (Thy-1+) stained positive using this antibody.
Background
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a heterodimer consisting of an α and β chain in 95% of T cells, while 5% of T cells have TCRs consisting of γ and δ chains. Engagement of the TCR with antigen and MHC results in activation of its T lymphocyte through a series of biochemical events mediated by associated enzymes, co-receptors and specialized accessory molecules.

Antigen Details

Research Area
Adaptive Immunity
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Immunology

References & Citations

1. Havran, et al. (1989) Pro. Natl. Acad. Sci. USA 86:4185
Flow Cytometry

Formats Available

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Products are for research use only. Not for use in diagnostic or therapeutic procedures.