Anti-Mouse Vγ 3 (TCR) – FITC

Anti-Mouse Vγ 3 (TCR) – FITC

Product No.: T135

[product_table name="All Top" skus="T135"]

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Clone
536
Target
Vγ 3 T-Cell Receptor
Formats AvailableView All
Product Type
Monoclonal Antibody
Isotype
IgG
Applications
FC

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Antibody Details

Product Details

Reactive Species
Mouse
Host Species
Syrian Hamster
Immunogen
AKR mouse dendritic epidermal cell clone 7-17
Product Concentration
0.2 mg/ml
Formulation
This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
Excitation Laser
Blue Laser (490 nm)
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Anti-Mouse Vγ 3 TCR antibody recognizes an epitope of the variable region (Vγ 3) gene product. Antibody from clone 536 immunoprecipitates the TCR heterodimer with two subunits of apparent molecular mass of 52 and 42 kDa.
Antigen Distribution
The antibody 536 stained less than 1% of cells in adult thymus (AKR), splenocytes, lymph node, adult CD4-8- thymocytes, and adult CD4-8-, T splenocyte. 92% of day 14 old BALB/C fetal thymus, 86% of C57BL/6 dEC (Thy-1+) and 94% of AKR dEC (Thy-1+) stained positive using this antibody.
Background
The T cell receptor or TCR is a molecule found on the surface of T lymphocytes that is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a heterodimer consisting of an α and β chain in 95% of T cells, while 5% of T cells have TCRs consisting of γ and δ chains. Engagement of the TCR with antigen and MHC results in activation of its T lymphocyte through a series of biochemical events mediated by associated enzymes, co-receptors and specialized accessory molecules.

Antigen Details

Research Area
Adaptive Immunity
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Immunology

References & Citations

Havran, et al. (1989) Pro. Natl. Acad. Sci. USA 86:4185
Flow Cytometry
Products are for research use only. Not for use in diagnostic or therapeutic procedures.