Anti-Myoferlin Antibody (90020)

Synthetic peptide derived from the N-terminal domain of the human FER1L3 protein. Accession no. Q9NZM1.

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml.

Lyophilized

Purified by Protein A affinity chromatography

This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.

Next Day 2-8°C

Mouse Monoclonal Antibody specific to Myoferlin

Ferlin proteins have been implicated in vesicle trafficking in a variety of physio- logical settings. All mammalian ferlins derive their names based on homology to the C. elegans protein FER-1 (FERtilization defective-1). FER1L3 (myoferlin, MYOF), has not yet been directly associated with a distinct mammalian disorder, but recent microarray and proteomic studies in the cancer literature have reported overexpression of MYOF in breast cancer specimens and relevant cell lines. Therefore, MYOF may be an important protein in breast cancer cells for their mobilization during cellular migration and/or invasion.

Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity). {ECO:0000250}.