Anti-NORE1 Antibody (34010)

Synthetic peptide corresponding to aa residues 313-329 (DNPQKFALFKRIHKDGQ) of human NORE1 conjugated to KLH.

PBS, pH 7.4.

Liquid

Purified by peptide immuno-affinity chromatography

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to NORE1

NORE1, first identified by its ability to bind to active Ras, is related in amino acid sequence to the tumor suppressor RASSF1. Expression of NORE1 suppresses colony formation by A549 and G361 cells, inhibits anchorage- independent growth by A549 cells and delays A549 progression through G1 without evidence of increased apoptosis. NORE1 suppresses the growth of tumor cell lines independent of Ras-like proteins or the protein kinases MST1 and 2.

Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {PubMed:12676952, PubMed:12845325, PubMed:15569673}.

Aoyama Y et al. (2004) Oncogene 23:3426-33.