Anti-Rhinovirus 16 [Clone R16-7]

Purified HRV16

This monoclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.2 - 7.4 with no carrier protein or preservatives added.

Liquid

Antibodies are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. Leinco Technologies provides "Gold Standard" quality for viral research. Our Clone R16-7 is manufactured under strict quality controls to ensure low endotoxin levels, making it ideal for sensitive assays where carrier proteins or preservatives might interfere with results.

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Next Day 2-8°C

Immunohistochemistry: use at 1-10ug/mL.

Clone R16-7 is a non-neutralizing antibody that recognizes the VP2 capsid protein (approx. 30 kDa). Its utility is enhanced by its ability to bind to critical precursors in the viral maturation pathway, including:

- VP0: The 37 kDa precursor of VP2 and VP4. - P1: The 90 kDa polyprotein precursor.

Beyond HRV16, this clone demonstrates valuable cross-reactivity with other major serotypes, including HRV1A, HRV39, HRV2, HRV14, and HRV49, making it a versatile reagent for multi-strain research.

Rhinoviruses (HRV), members of the Picornaviridae family, are ubiquitous and highly prevalent RNA viruses. These small, non-enveloped pathogens are characterized by their icosahedral capsid and a single-stranded, positive-sense RNA genome. The viral genome uniquely encodes a single polyprotein that is subsequently cleaved by viral proteases into essential structural and non-structural proteins, vital for viral replication and assembly. Rhinovirus 16 (HRV16) is one of the most extensively studied serotypes due to its role in:

- Asthma & COPD Exacerbations: HRV16 is a major trigger for severe lower airway symptoms in vulnerable patients.

- Viral Replication Studies: It serves as a model organism for understanding the Picornaviridae life cycle, including polyprotein cleavage and capsid assembly.

With over 100 known serotypes, Human Rhinoviruses are the primary cause of the common cold, leading to millions of upper airway infections annually. Beyond acute symptoms, HRV infections pose a significant health burden by exacerbating lower airway symptoms in vulnerable patient populations. They are well-documented triggers for severe complications in individuals suffering from asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD), often leading to increased hospitalizations and diminished quality of life.

Our Anti-Rhinovirus 16 monoclonal antibody, Clone R16-7, is specifically developed to target Rhinovirus 16. This highly specific tool is indispensable for researchers investigating HRV pathogenesis, viral diagnostics, and the development of new antiviral therapies or vaccines. Leverage Clone R16-7 for precise detection and characterization of Rhinovirus 16 in your studies.

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2) Mosser AG et al. 2005 Am J Respir Crit Care Med 171: 645.
3) Jurgeit A et a. 2010 Virology J 7: 264.
4) Chattoraj SS et al. 2011 Infect Immun 79: 4131.