Anti-SHPRH Antibody (34009)

Product No.: 34009


Target SHPRH Product Type Polyclonal Alternate Names EC 2.3.2.27, EC 3.6.4.-, RING-type E3 ubiquitin transferase SHPRH, SNF2, histone-linker, PHD and RING finger domain-containing helicase Applications ELISA , WB


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Antibody Details Product Details Reactive Species Human Host Species Rabbit Immunogen Synthetic peptide corresponding to aa residues 515-535 (DKTKKQAVGSPRKIEKELRKS) of mouse SHPRH conjugated to KLH at the N-terminus. Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting : use at 1:250 dilution. Positive control: Mouse brain lysate. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity Rabbit Polyclonal Antibody specific to SHPRH Antibody Background A novel gene containing SNF2, PHD- finger, RING-finger, helicase, and linker histone domains termed SHPRH, is a possible candidate for a tumor suppressor gene. These domains are characteristic of several DNA repair proteins, transcription factors, and helicases. Mapping of this gene to 6q24, a region reported to contain a tumor suppressor locus, suggests a role for SHPRH in tumor suppression. Function E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. {PubMed:17108083, PubMed:17130289, PubMed:18719106}. NCBI Gene Bank ID SHPRH UniProt.org Q149N8 Research Area Cancer Research References & Citations Sood R. et al. (2003) Genomics 82:153-161. View product citations for antibody 34009 on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

Host Species

Rabbit

Immunogen

Synthetic peptide corresponding to aa residues 515-535 (DKTKKQAVGSPRKIEKELRKS) of mouse SHPRH conjugated to KLH at the N-terminus.

Product Concentration

Lot Specific

Formulation

PBS, pH 7.4.

State of Matter

Liquid

Product Preparation

Purified by peptide immuno-affinity chromatography

Storage and Handling

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Country of Origin

USA

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunoblotting : use at 1:250 dilution.

Positive control: Mouse brain lysate.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rabbit Polyclonal Antibody specific to SHPRH Antibody

Background

A novel gene containing SNF2, PHD- finger, RING-finger, helicase, and linker histone domains termed SHPRH, is a possible candidate for a tumor suppressor gene. These domains are characteristic of several DNA repair proteins, transcription factors, and helicases. Mapping of this gene to 6q24, a region reported to contain a tumor suppressor locus, suggests a role for SHPRH in tumor suppression.

Function

E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. {PubMed:17108083, PubMed:17130289, PubMed:18719106}.

NCBI Gene Bank ID

SHPRH

UniProt.org

Q149N8

Research Area

Cancer Research