Anti-Tumor Endothelial Marker 5
Anti-Tumor Endothelial Marker 5
Product No.: 34028
Data
Immunohistochemistry: - -
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Antibody DetailsProduct DetailsReactivity Species Human Host Species Rabbit Immunogen Synthetic peptide conjugated to KLH Product Concentration Lot Specific Formulation PBS containing 0.1% sodium azide State of Matter Liquid Product Preparation Purified by immunogen affinity chromatography Storage and Handling This antibody is stable at 4°C (short- term) and -70°C (long-term). Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunohistochemistry: Use at 10 ug/ml. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Polyclonal Antibody specific to Tumor Endothelial Marker 5 Background Tumor endothelial marker 5 (TEM5) is a member of the adhesion family of GPCRs and is upregulated in endothelial cells during tumor and physiologic angiogenesis. Soluble TEM5 (sTEM5) is shed by endothelial cells during angiogenesis and binds to glycosaminoglycans on extracellular matrix and cell surface proteoglycans. After proteolytic processing, an RGD- binding site for integrin alphavbeta3 is exposed on sTEM5. Adhesion of endothelial cells to immobilized proteolytically processed sTEM5 promotes their survival. Antigen DetailsNCBI Gene Bank ID UniProt.org Research Area Cancer Research References & Citations IHC-P |
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