Anti-WWOX Antibody (34016)

Synthetic peptide corresponding to amino acids 89-107 (RLAFTVDDNPTKPTTRQRY) of human WWOX conjugated to KLH at the C- terminus.

PBS, pH 7.4.

Liquid

Purified by peptide immuno-affinity chromatography

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Next Day 2-8°C

Rabbit Polyclonal Antibody specific to WWOX Antibody

WW domain-containing oxidoreductase, WWOX, also known as WOX1 or FOR, is a proapoptotic protein expressed by a tumor suppressor gene. Because mutation or deletion in the coding region of WWOX is rarely found, it is speculated that the appearance of aberrant transcripts affects progression of many cancers. In addition, protein levels of WWOX, its Tyr33- phosphorylated form, and WOX2 are significantly down-regulated in the neurons of Alzheimer's hippocampi.

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. {PubMed:11719429, PubMed:15070730, PubMed:15548692, PubMed:16061658, PubMed:16219768, PubMed:19366691, PubMed:19465938}.

Chang, N.S et al. Oncogene (2005) 24: 714-723.
Aqeilan, R.I. et al. Cancer Res (2004) 64: 8256-8261.
Sze, C.I. et al. J Biol Chem (2004) 279: 30498-30506.