DR6 (NT) Blocking Peptide

DR6 (NT) Blocking Peptide

Product No.: D280

[product_table name="All Top" skus="D280"]

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Death Receptor 6
Product Type
Blocking Peptide
Alternate Names

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Antibody Details

Product Details

Reactive Species
Product Concentration
0.2 mg/ml
Amino Acid Location
This peptide sequence is located at amino acids 42 to 56 of Human DR6 protein.
This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide.
Storage and Handling
Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Country of Origin
Next Day Ambient
Amino Acid Sequence
15 amino acids of human DR6.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Death receptor-6 (DR6), a member of the death domain-containing TNFR superfamily, is highly expressed in lymphoid tissues and regulated upon lymphocyte activation. Targeted disruption of DR6 results in enhanced CD4(+) T cell proliferation and T helper 2 differentiation in vitro.1 DR6 contains an extracellular region and an intracellular region; the intracellular region harbors a death domain that is critical for transduction of apoptotic signals.2 DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK.

Antigen Details

References & Citations

1. Na, S. et al.(2006)Immunol Lett. 106:42
2. Shi, J. et al. (2018) FEBS Open Bio. 8(9):1497-1507.
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.