BCMA, also known as TNFRSF17, is a type III membrane protein and member of the TNF receptor superfamily, which are critically involved in the maintenance of homeostasis of the immune system (1). BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment (2). Both BAFF and APRIL are ligands for BCMA (4-5). BCMA/BAFF binding induces B cell development and survival, activates NF-κB and c-jun N-terminal kinase, and is involved in B cell associated autoimmune diseases. The binding of BCMA to APRIL has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells (4). This data suggests that BCMA may play an important role in B cell development, function and regulation. BCMA also binds B-lymphocyte stimulator (BLyS) (6).
>95% by SDS-PAGE and analyzed by silver stain.
<0.1 EU/µg as determined by the LAL method
The biological activity of Human BCMA was determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated mouse B cells. The expected ED50 for this effect is typically 0.01 - 0.04 μg/ml in the presence of 100 ng/ml of rhAPRIL.
Fusion Protein Tag
Fc Fusion Protein
Protein Accession No.
Amino Acid Sequence
mlqmagqcsq neyfdsllha cipcqlrcss ntppltcqry cnasvtnsvk gtnaiegrmd pkscdkthtc ppcpapellg gpsvflfppk pkdtlmisrt pevtcvvvdv shedpevkfn wyvdgvevhn aktkpreeqy nstyrvvsvl tvlhqdwlng keykckvsnk alpapiekti skakgqprep qvytlppsrd eltknqvslt clvkgfypsd iavewesngq pennykttpp vldsdgsffl yskltvdksr wqqgnvfscs vmhealhnhy tqkslslspg k
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human BCMA is Mr 32 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 35-45 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Zhou, T. et al. (2002) Immunol. Res. 26:323
2. Gras, M. et al. (1995) Int. Immunol. 7:1093
3. Hatzoglou, A. et al. (2000) J. Immunol. 165:1322
4. Marsters, S. et al. (2000) Curr. Biol. 10:785
5. Kwon, B. et al. (1999) Curr. Opin. Immunol. 11:340
6. Gross, JA. et al. (2000) Nature 404:995
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.