Recombinant Human CCL17/TARC

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Pricing & Details

Product. No.T158
Alternate Names
Thymus and Activation Regulated Chemokine (TARK), A-152E5.3, ABCD-2, MGC138271, MGC138273, SCYA17, TARC, Dendrokine
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
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Qty
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T158-25 µg
25 µg
$309.00
In stock
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Min: 1
Step: 1

Background

CCL17 is a small cytokine belonging to the CC chemokine and is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells.1 This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.1,2 CCL17 may be a useful serological marker and may facilitate an assessment of the degree of disease activity in systemic lupus erythematosus (SLE).3 It may also participate in the pathogenesis of skin diseases such as atopic dermatitis (AD) by regulating both allergic and irritant inflammation.4

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.01 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human Thymus and Activation Regulated Chemokine is determined by its ability to chemoattract human T cells using a concentration range of 1.0-10.0 ng/ml.
Expression Host
E. coli
Protein Accession No.
Amino Acid Sequence
argtnvg reccleyfkg aiplrklktw yqtsedcsrd aivfvtvqgr aicsdpnnkr vknavkylqs lers
N-terminal Sequence Analysis
Ala24
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CCL17 is Mr 8.0 kDa.
Formulation
This recombinant protein was lyophilized from a 24.0 μL of a 0.2 μm filtered solution in 30% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank

References & Citations

1. Yoshie, O. et al. (1996) J Biol Chem. 271: 21514
2. Yoshie, O et al. (1997) J Biol Chem. 272: 15036
3. Kamatani, N. et al. (2003) J Rheumatology 30: 2369
4. Kunihiko, K. et al. (2006) Eur J Immunol. 36: 2116
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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