Anti-Mouse CCL17 (Clone 110904)

Pricing & Details

Product No.C1435
Clone
110904
Protein
CCL17
Formats AvailableView All
Product Type
Monoclonal Antibody
Alternate Names
TARK, ABCD-2, MGC138271, SCYA17, TARC
Isotype
Rat
IgG2a
Applications
ELISA Cap
,
N
Prod No.
Size
Price
Avail.
Qty
Add to cart
C1435-25 µg
25 µg
$185.00
In stock
Max:
Min: 1
Step: 1
C1435-100 µg
100 µg
$389.00
In stock
Max:
Min: 1
Step: 1
C1435-500 µg
500 µg
$960.00
In stock
Max:
Min: 1
Step: 1
Bulk quantities available. Contact us for pricing.

Antibody Details

Product Details

Reactivity Species
Mouse
Host Species
Rat
Immunogen
Purified Recombinant Mouse CCL17 (Accession No.: Q9WUZ6)
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Formulation
This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Storage and Handling
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Country of Origin
USA
Shipping
Next Day Ambient
Applications and Recommended Usage?
Quality Tested by Leinco
ELISA Sandwich: This antibody is useful as the capture antibody in a sandwich ELISA. The suggested coating concentration is 2 µg/ml. A suitable detection antibody is PN:C1510 at a concentration of approximately 0.1-0.4 µg/ml. When used in conjunction with an optimal second step reagent such as PN:A106 and a chromogenic substrate such as PN:T118, the sensitivity of this sandwich ELISA is 2 ng/well. A suggested standard for this assay is PN:T397.
Other Applications Reported In Literature ?
Neutralization: This antibody is useful for neutralization of Mouse CCL17 bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Mouse CCL17 (at 20 ng/ml) is 0.75 - 30 µg/ml.
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity
Rat Anti-Mouse CCL17 (Clone 110904) recognizes an epitope on Mouse CCL17. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Chemokine (C-C motif) ligand 17 (CCL17) is a small cytokine belonging to the CC chemokine and is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells.1 This chemokine specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4.1,2 CCL17 may be a useful serological marker and may facilitate an assessment of the degree of disease activity in systemic lupus erythematosus (SLE).3 It may also participate in the pathogenesis of skin diseases such as atopic dermatitis (AD) by regulating both allergic and irritant inflammation.4

Antigen Details

Protein
PubMed

References & Citations

1. Yoshie, O. et al. (1996) J Biol Chem. 271: 21514
2. Yoshie, O. et al. (1997) J Biol Chem. 272: 15036
3. Kamatani, N. et al. (2003) J Rheumatology 30: 2369
4. Kunihiko, K. et al. (2006) Eur J Immunol. 36: 2116
Elisa Sandwich Protocol

Formats Available

Prod No.
Description
C1435
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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