Recombinant Human CCL21 (Mucin)

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC). CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.

In the cancer biology CCL21 seems to have multifaceted roles. CCL21 attracts CCR7 bearing cells especially T and dendritic cells but also various cancer cells. Besides the antitumour role as leukocyte recruiting, CCL21 has been shown to facilitate dendritic cell functions and to exert an angiostatic effect.

Human and mouse 6Ckine are highly conserved, exhibiting 86% amino acid sequence identity.

Histidine Tag

NP_002980 & P78423

(Human 6Ckine) sdggaqdccl kysqrkipak vvrsyrkqep slgcsipail flprkrsqae lcadpkelwv qqlmqhldkt pspqkpaqgc rkdrgasktg kkgkgskgck rtersqtpkg pgs, (Human Fractalkine mucin-like stalk) fekqigevkp rttpaaggmd esvvlepeat gesssleptp ssqeaqralg tspelptgvt gssgtrlppt pkaqdggpvg telfrvppvs taatwqssap hqpgpslwae aktseapstq dpstqastas spapeenaps egqrvwgqgq sprpensler eemgpvpaht dafqdwgpgs mahvsvvpvs segtpsrepv asgswtpkae epihatmdpq rlgvlitpvp daqaatrrqk qnhhhhhh

Ser24

Lyophilized

The predicted molecular weight of Recombinant Human 6Ckine is Mr 38.3 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 95-105 kDa.

38.3

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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