Recombinant Human CCL27

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Pricing & Details

Product. No.C841
Alternate Names
ALP, ILC, Eskine, Cutaneous T-Cell Attracting Chemokine, CTACK, SCYA27, Skinkine, PESKY
Expression Host
E. coli
Species
Human
Prod No.
Size
Price
Avail.
Qty
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C841-25 µg
25 µg
$249.00
In stock
Max:
Min: 1
Step: 1
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Background

Chemokine (C-C motif) ligand 27 (CCL27) is a small cytokine belonging to the CC chemokine family. It is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin. CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.

CCL27 is one of the CC chemokines produced by epidermal keratinocytes and is suggested to be involved in the pathogenesis of inflammatory skin diseases. CCL27 modifies inflammation by attracting CCR10-positive and CCR4-positive cells into the lesional skin, and may participate in the pathogenesis of Th2-shifted skin diseases such as atopic dermatitis.

Protein Details

Purity
>97% by SDS-PAGE and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Biological Activity
The biological activity of Human CTACK was determined by its ability to induce chemotaxis of mouse BaF/3 cells transfected with mCCR10. The expected ED50 for this effect is typically 0.1 - 0.4 μg/ml.
Expression Host
E. coli
Protein Accession No.
Q9Y4X3.1
Amino Acid Sequence
fllppstacc tqlyrkplsd kllrkviqve lqeadgdchl qafvlhlaqr sicihpqnps lsqwfehqer klhgtlpkln fgmlrkmg
N-terminal Sequence Analysis
Phe25
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CTACK is Mr 10.1 kDa.
Formulation
This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient
PubMed
NCBI Gene Bank
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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