CCL4L1/platelet factor-4 variant (PF-4var), is a highly angiostatic chemokine1 and a potent regulator of endothelial cell biology, which affects angiogenesis and vascular diseases.2 CXCL4 is a member of the CXC chemokine family, which is mainly produced by platelets and known for its pleiotropic biological functions. CXCL4L1 exhibits a distinct subcellular localization has a distinct roles in inflammatory or homeostatic processes.3
>95% by SDS-PAGE and analyzed by silver stain.
<0.1 EU/µg as determined by the LAL method
The biological activity of Human CCL4L1 was determined by its ability to chemoattract human CCR5 transfected BaF3 mouse proB cells. The expected ED50= 0.5-2.5 ng/ml.
Protein Accession No.
Amino Acid Sequence
apmgsdppta ccfsytarkl prnfvvdyye tsslcsqpav vfqtkrgkqv cadpseswvq eyvydleln
N-terminal Sequence Analysis
State of Matter
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human CCL4L1 is Mr 7.8 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 12 kDa.
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
Next Day Ambient
NCBI Gene Bank
References & Citations
1. Struyf, S. et al.(2007) J. Leukos Biol. 82: 1519
2. Strieter, RM. et al.(2004) Circ Res. 95(9):855-7.
3. Romagnani, P. et al.(2007) Blood 109: 4127
IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Products are for research use only. Not for use in diagnostic or therapeutic procedures.